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association of a rare thyroglobulin gene microsatellite

association of a rare thyroglobulin gene microsatellite

association of a rare thyroglobulin gene microsatellite

Analysis of thyroglobulin gene polymorphisms in patients

Mar 18, 2010 · The autoimmune thyroid disease is a complex disorder caused by a combination of genetic susceptibility and environmental factors, which are believed to initiate the autoimmune response to thyroid antigens. Identification of the susceptibility genes has found that unique and diverse genetic factors are in association with Graves disease and autoimmune thyroiditis. The thyroglobulin gene Association of Autoimmune Thyroid Disease with TSHRCA and another TSHR microsatellite marker, TSHR-AT, which is located in intron 2 of TSHR gene, were genotyped in a set of 349 unrelated Japanese AITD patients and 218 Japanese controls. The TSHR-AT marker showed association in this Japanese AITD population with a significant increase in allele 5 (294 bp; p < 0.05) and a significant decrease in allele 7 (298 bp; p < 0.05).

Association of CSSM066 and ILSTS011 microsatellite

Association of CSSM066 and ILSTS011 microsatellite markers and thyroglobulin gene SNP with backfat in Canchim cattle Association of CSSM066 and ILSTS011 microsatellite The CSSM066 and ILSTS011 microsatellite markers have a effect on fat thickness in the studied populations. However, this trait did not have association with the polymorphism of the thyroglobulin gene, which suggests that other genes of bovine chromosome 14 may be responsible for the variation in Association of CSSM066 and ILSTS011 microsatellite The CSSM066 and ILSTS011 microsatellite markers have a effect on fat thickness in the studied populations. However, this trait did not have association with the polymorphism of the thyroglobulin gene, which suggests that other genes of bovine chromosome 14 may be responsible for the variation in

Association of a rare thyroglobulin gene microsatellite

Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease. By JE Collins, JM Heward, J Carr-Smith, J Daykin, JA Franklyn and SC Gough No static citation data No static citation data Cite Association of the TGrI29 microsatellite in thyroglobulin Association of the TGrI29 microsatellite in thyroglobulin gene with autoimmune thyroiditis in a Argentinian population:A case-control study October 2010 Endocrine 38(3):320-7 Association of the TGrI29 microsatellite in thyroglobulin Endocr (2010) 38:320327 DOI 10.1007/s12020-010-9398-1 ORIGINAL ARTICLE Association of the TGrI29 microsatellite in thyroglobulin gene with autoimmune thyroiditis in a Argentinian population:a casecontrol study Viviana Varela Leonardo Rizzo Sabina Domene´ Oscar D. Bruno Mariana L. Tellechea Carina M. Rivolta He´ctor M. Targovnik Received:13 May 2010 / Accepted

Association of the TGrI29 microsatellite in thyroglobulin

However, when we analyzed autoimmune thyroiditis patients with the TGrI29 microsatellite we found a significant association between the 197-bp allele and autoimmune thyroiditis (33.50% vs. 19.00% in control group) (P=0.001). Association of the TGrI29 microsatellite in thyroglobulin J.E. Collins, J.M. Heward, J. Carr-Smith, J. Daykin, J.A. Franklyn, S.C. Gough, Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease. J. Clin. Association of the TGrI29 microsatellite in thyroglobulin We studied six Polymorphism polymorphisms distributed throughout all the thyroglobulin gene:four microsatellites (Tgms1, Tgms2, TGrI29, and Abbreviations TGrI30), one insertion/deletion polymorphism (IndelTG- AITD Autoimmune thyroid diseases IVS18), and one exonic single nucleotide polymorphism AT Autoimmune thyroiditis (c.7589G[A) in 100 AT patients and 100 healthy control GD Graves disease

Autoimmune thyroid diseases:genetic susceptibility of

Mutations in TPO gene are responsible to genetic defect in thyroid hormonogenesis often caused by a total iodide organification defect (Bikker et al., 1994, 1995, 1996, 1997 and Bakker et al., 2000). The association between microsatellite polymorphism of TPO gene and GD was carried out by Pirro et al . in 1995 , and the hypotheses of involvement of this gene in GD genetic susceptibility are rejected. Multiple SNPs in Intron 41 of Thyroglobulin Gene - COREAssociation between a C/T polymorphism in exon 33 of the thyroglobulin gene is associated with relapse of Graves hyperthyroidism after antithyroid withdrawal in Taiwanese. (2003). Association of a rare thyroglobulin gene microsatellite variant with autoimmune thyroid disease. The thyroglobulin gene as the first thyroid-specific Jul 01, 2004 · Recent linkage and association studies provide evidence for thyroglobulin (Tg) being an autoimmune thyroid disease (AITD) susceptibility gene.The Tg locus has been reported to be linked with AITD in two independent studies, and further analysis demonstrated that markers within the Tg gene were associated with AITD. Furthermore, missense single-nucleotide polymorphisms (SNPs) in the Tg gene

The thyroglobulin gene as the first thyroid-specific

Recent linkage and association studies provide evidence for thyroglobulin (Tg) being an autoimmune thyroid disease (AITD) susceptibility gene. The Tg locus has been reported to be linked with AITD in two independent studies, and further analysis demonstrated that markers within the Tg gene were associated with AITD. Furthermore, missense single-nucleotide polymorphisms (SNPs) in the Tg gene The thyroglobulin gene:the third locus for autoimmune Genetic-linkage studies have implicated chromosome 8q24 as a susceptibility locus for AITD. The gene encoding thyroglobulin (Tg), which encodes a major thyroid autoantigen, maps to this region, and a recent study has reported the association of several exonic Association of a Rare Thyroglobulin Gene Microsatellite Recent studies have demonstrated an association between thyroglobulin (Tg) polymorphisms and AITD in Caucasians, suggesting that Tg is a susceptibility gene on 8q24.

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